224+ Vacation Rentals Near Santee National Wildlife Refuge |
  1. USA
  2. South Carolina
  3. Sumter
  4. Santee National Wildlife Refuge

Villa Holiday Cyprus - Vacation Rentals in Santee National Wildlife Refuge

Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS in Summerton From US $341
         

10.0 (177 Reviews)
House
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
  • Air Conditioner
  • Parking
  • TV

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Club Wyndham Lake Marion in Santee From US $139
         

10.0 (4 Reviews)
Resort
Club Wyndham Lake Marion
  • Air Conditioner
  • Parking
  • Pool

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Fairfield Inn & Suites by Marriott Santee in Santee From US $171
         

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9.8 (1013 Reviews)
Hotel
Fairfield Inn & Suites by Marriott Santee
  • Air Conditioner
  • Parking
  • Pool

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Lake Marion Lakehouse with 180° lake view in Elloree From US $316
         

10.0 (93 Reviews)
House
Lake Marion Lakehouse with 180° lake view
  • Air Conditioner
  • Parking
  • Designated Smoking Area

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Idyllic Waterfront Escape w/Private Boat Dock! in Santee From US $394
         

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10.0 (1 Review)
House
Idyllic Waterfront Escape w/Private Boat Dock!
  • Parking
  • View
  • Ocean View

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Hampton Inn Santee-I-95 in Santee From US $142
         

9.6 (1001 Reviews)
Hotel
Hampton Inn Santee-I-95
  • Air Conditioner
  • Parking
  • Pool

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Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! in Santee From US $334
         

10.0 (46 Reviews)
House
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
  • Air Conditioner
  • Parking
  • Pet Friendly

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Life is Marion the Lake in Santee From US $191
         

10.0 (1 Review)
Apartment
Life is Marion the Lake
  • Air Conditioner
  • Parking
  • Designated Smoking Area

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Country living lake style near Santee in Summerton From US $214
         

10.0 (46 Reviews)
House
Country living lake style near Santee
  • Child Friendly

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Waterfront Lake Marion Retreat Pool Gazebo Minutes from I-95 in Santee From US $266
         

10.0 (17 Reviews)
Condo
Waterfront Lake Marion Retreat Pool Gazebo Minutes from I-95
  • Air Conditioner
  • Parking
  • Pool

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Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing! in Santee From US $507
         

10.0 (15 Reviews)
Condo
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
  • Air Conditioner
  • Parking
  • TV

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Lakefront Stay on Santee in Summerton From US $616
         

10.0 (14 Reviews)
House
Lakefront Stay on Santee
  • Air Conditioner
  • TV
  • View

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Lake Marion - Majestic Big Water View! in Santee From US $380
         

10.0 (13 Reviews)
Condo
Lake Marion - Majestic Big Water View!
  • Air Conditioner
  • Parking
  • Pet Friendly

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Lakefront Retreat on Lake Marion – Perfect for Fishing & Relaxation in Santee From US $274
         

10.0 (9 Reviews)
Condo
Lakefront Retreat on Lake Marion – Perfect for Fishing & Relaxation
  • Air Conditioner
  • Parking
  • TV

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CatDaddy Cabin - Lake Marion Cabin in Santee - lake view, fire pit, boat parking in Santee From US $311
         

10.0 (3 Reviews)
Cabin
CatDaddy Cabin - Lake Marion Cabin in Santee - lake view, fire pit, boat parking
  • Air Conditioner
  • Parking
  • Designated Smoking Area

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Cottage at Gordon Cove - Pets Allowed/No Pet Fee in Summerton From US $336
         

10.0 (2 Reviews)
Cottage
Cottage at Gordon Cove - Pets Allowed/No Pet Fee
  • Air Conditioner
  • Parking
  • Pet Friendly

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Sunset Serenity, Lake Marions Ultimate Dream Getaway Pool/swimspa/sleeps 16 in Summerton From US $1,092
         

10.0 (1 Review)
House
Sunset Serenity, Lake Marions Ultimate Dream Getaway Pool/swimspa/sleeps 16
  • Air Conditioner
  • Parking
  • Pet Friendly

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Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8 in Summerton From US $533
         

10.0 (1 Review)
Cabin
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
  • Air Conditioner
  • Parking
  • TV

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2 Mi to Lake Marion! Pet-Friendly Home w/Yard in Santee From US $319
         

10.0 (1 Review)
House
2 Mi to Lake Marion! Pet-Friendly Home w/Yard
  • Air Conditioner
  • Pet Friendly
  • TV

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3-bedroom house in fabulous Summerton next to lake in Summerton From US $302
         

10.0 (1 Review)
House
3-bedroom house in fabulous Summerton next to lake
  • Air Conditioner
  • Parking
  • TV

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Idyllic Waterfront Escape w/Private Boat Dock! in Summerton From US $507
         

9.8 (28 Reviews)
House
Idyllic Waterfront Escape w/Private Boat Dock!
  • Air Conditioner
  • Parking
  • Pool

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Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss in Santee From US $204
         

9.6 (18 Reviews)
Condo
Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss
  • Air Conditioner
  • Parking
  • Pet Friendly

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Life is better at the Lake Lakefront home that sleeps 13! in Summerton From US $450
         

9.4 (16 Reviews)
House
Life is better at the Lake Lakefront home that sleeps 13!
  • Air Conditioner
  • Parking
  • Pet Friendly

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Lakeside vacationing close to golf courses, restaurants and boat rental company! in Santee From US $281
         

9.2 (11 Reviews)
Condo
Lakeside vacationing close to golf courses, restaurants and boat rental company!
  • Air Conditioner
  • Parking
  • Pool

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★ Pro Tip: Villaholidaycyprus makes it easy to compare the best listings on Villaholidaycyprus homes from online vacation rental OTAs, including Booking.com and more. Use the Advanced Filter feature at the top to easily flip between Villaholidaycyprus homes, vacation rentals, bed and breakfasts, private Airbnb-style rentals availability, eco-friendly properties, property type, cancellation policies, prices, and several different options. All these make it easier to find the perfect accommodation for your next vacation in Santee National Wildlife Refuge.

Weather in Santee National Wildlife Refuge

View the weather forecast for Santee National Wildlife Refuge before booking your Santee National Wildlife Refuge Vacation Rentals to confirm your best time to go.

December - February
High 60°F       Low 26°F
March - May
High 77°F       Low 40°F
June - August
High 91°F       Low 64°F
September - November
High 84°F       Low 38°F

Top Attractions Around Santee National Wildlife Refuge, SC

Villaholidaycyprus offers a large selection of top attractions around Santee National Wildlife Refuge. Research things to do on your vacation before you visit Santee National Wildlife Refuge.


Lake Marion Shaw Air Force Base Congaree National Park Santee State Park Dillion Park South Carolina State University Lake Moultrie St. George United Methodist Church Santee Cooper Country Club Sumter Mall O'Donnell House Swan Lake Iris Gardens St. George Country Club Santee Outlets Palmetto Tennis Center Palmetto Park Wyboo Golf Club Santee National Golf Club Borough House Plantation Sumter County Gallery of Art

Santee National Wildlife Refuge Vacation Rental Frequently Asked Questions

How many vacation rentals are available in Santee National Wildlife Refuge?

Currently, the total number of properties listed in 2026 is over 224 in the Santee National Wildlife Refuge area, and still counting. By aggregating listings from multiple websites, offers an immense amount of choice of the best properties in Santee National Wildlife Refuge.